带引导程序的复杂网格

如何解决带引导程序的复杂网格

我想在CSS中进行这样的设计，但是蓝色div下方没有空白，并且每个空白之间都有一个空白。

我尝试了不同的操作，但不可能做到这一点，我的div总是换行...

非常感谢您！

这是我的代码（简体）

.row > div { border: 1px solid black;}
.A {height:420px;}
.D {height:200px;}
.E {height:200px;}
.B {height:300px;}
.C {height:300px;}

<div class="container">
    <div class="row">
      <div class="col-md-8 col-lg-6 A">
        <div>
          A
        </div>
      </div>
      <div class="col-md-12 col-lg-6 B">
        <div>
          B
        </div>        
      </div>
      <div class="col-md-12 col-lg-6 C">
        <div>
          C
        </div>        
      </div>
      <div class="col-md-4 col-lg-3 D">
        <div>
          D
        </div> 
      </div>
      <div class="col-md-4 col-lg-3 E">
        <div>
          E
        </div>         
      </div>
    </div>
  </div>

解决方法

有了Flexbox，无需使用引导程序或网格！

.topmost-wrapper {
  height: 100vh;
  width: 65%;
  margin: 0 auto;
  display: flex;
  flex-direction: row;
}

.sub-wrap-1 {
  display: flex;
  flex-direction: column;
  flex: 0.5 1 0;
  height: 100%;
  margin-right: 0.125rem;
}

.inner-1 {
  flex: 0.7 1 0;
  background: lightblue;
  margin-bottom: 0.0925rem;
  border-radius: 0.1825rem;
}

.inner-2 {
  flex: 0.3 1 0;
  display: flex;
  flex-direction: row;
  margin-top: 0.0925rem;
}

.in-inner-1 {
  flex: 0.7 1 0;
  background: lightgreen;
  margin-right: 0.0825rem;
  border-radius: 0.1825rem;
}

.in-inner-2 {
  flex: 0.3 1 0;
  background: lightsalmon;
  margin-left: 0.0825rem;
  border-radius: 0.1825rem;
}

.sub-wrap-2 {
  display: flex;
  flex-direction: column;
  flex: 0.5 1 0;
  height: 100%;
  margin-left: 0.125rem;
}

.inner-3 {
  flex: 0.5 1 0;
  background: grey;
  margin-bottom: 0.0925rem;
  border-radius: 0.25rem;
}

.inner-4 {
  flex: 0.5 1 0;
  background: #3e3e3e;
  margin-top: 0.0925rem;
  border-radius: 0.25rem;
}

<div class='topmost-wrapper'>


  <div class="sub-wrap-1">

    <div class="inner-1"></div>

    <div class="inner-2">
      <div class="in-inner-1"></div>
      <div class="in-inner-2"></div>
    </div>

  </div>

  <div class='sub-wrap-2'>

    <div class="inner-3"></div>
    <div class="inner-4"></div>

  </div>


</div>